Amazentis Closes $9 Million Series C Financing

Amazentis develops the next generation of products targeting mitochondrial health for advanced nutrition and pharma applications. Mitochondria are the organelles that generate energy for the cell. Amazentis’ proprietary lead product candidate, AMAZ-02, an oral formulation of urolithin A, is a naturally occurring metabolite. Oral administration of urolithin A leads to improved mitochondrial function.

The oversubscribed financing included participation of an additional new investor along with existing investors. Proceeds of the financing will be used to advance clinical trials of the Company’s proprietary lead product candidate, AMAZ-02, an oral formulation of urolithin A, and to prepare for future commercial activities with AMAZ-02.

In addition, Amazentis announced the initiation of and study recruitment for the Company’s two pivotal, double-blind, randomized, placebo-controlled Phase 2 trials of AMAZ-02:

• The ENERGIZE Trial, designed to assess the effects of AMAZ-02 on improving mitochondrial and muscle function in healthy elderly individuals (>65 years old) who have low skeletal muscle mitochondrial function (NCT03283462).

• The ATLAS Trial, focused on the potential of AMAZ-02 to improve physical endurance and muscle power in healthy overweight middle-aged participants (40 to 65 years old) who have low exercise tolerance. (NCT03464500).

“There are currently no effective approaches to treat age-related decline in muscle function, other than months of exercise training, and nutritional strategies have had limited impact. This new clinical program, the first of its kind to test urolithin A in pivotal studies in humans, is designed to provide scientific validation for an urgently needed solution to support healthy aging,” commented Kevin Conley, PhD, Professor in the Departments of Radiology and Physiology & Biophysics, University of Washington, Seattle, and the Principal Investigator in the ENERGIZE Trial.

“We are very pleased with the strong interest and support from the clinical community, as well as the commitment from our investors participating in the current Series C round as we advance urolithin A through these next milestones and onward,” commented Patrick Aebischer, MD, Chairman and co-founder of Amazentis and President Emeritus at the École Polytechnique Fédérale de Lausanne (EPFL), Switzerland. “Amazentis is dedicated to establishing the full potential of urolithin A. We look forward to the progress of both the ENERGIZE and ATLAS studies, which are expected to report results next year. With this current financing, Amazentis is well positioned as we set the stage to bring urolithin A to market,” stated Chris Rinsch, PhD, CEO and co-founder of Amazentis.

(Press release)