Preclin Biosystems part of a major EU project

The EUR 5.5 million funding will be used to complete pre-clinical tests as well as a Phase I clinical trial in humans in 2016. The Bellerophon Project forms part of the 2012-2013 edition of the Seventh Framework Programme initiated by the European Community for Research, Technological Development and Demonstration Activities (FP7).

The bacterium S. aureus causes a range of serious infections in humans. It is responsible for approximately 16,000 deaths annually in Europe and 19,000 in the US. Additional studies suggest at least EUR 380 million annual European costs attributable to S. aureus, as well as several billion USD per annum in the USi. The emergence of highly antibiotic resistant S. aureus strains, such as MRSA (Methicillin-resistant S. aureus), is creating a serious public health threat around the world and an increasing economic burden. There continues to be a high unmet medical need as recent vaccine candidates have not proven effective in large human clinical studies.

The pan-European Bellerophon Project is comprised of four European institutions involved in vaccine development, each contributing specialist expertise and technology. It includes Imaxio, a French biotech company focused in immunology, which has coordinated the grant application, and the Jenner Institute at Oxford University, UK, an academic institution with key expertise on S. aureus antigens and viral vector delivery systems, which will coordinate the overall project.

The consortium also includes the European Vaccine Initiative, a non-for-profit organization based in Germany specialized in vaccine development programs and coordination of European institutions. The fourth member is Preclin Biosystems, a Swiss contract research organization that has a strong expertise in preclinical efficacy models for infectious diseases.

“We are very proud to be part of the Bellerophon Project consortium with such prestigious partners,” said Dr. Bettina Ernst, chief executive officer of Preclin Biosystems. “We strongly believe our solid infectious models will successfully push this vaccine forward through preclinical trials up to 2015.”

Preclin Biosystems AG is a privately owned company founded in June 2008 which offers a comprehensive in vivo preclinical testing platform for the identification and validation of lead candidate therapeutics.