More news about leadXpro

Leadxpro collaborates with Sanofi on a research project

17.12.2018 15:30

Related tags


The drug discovery company, Leadxpro and the pharma giant Sanofi are combining their expertise in structure-based drug discovery for a challenging drug target. The joint research project is based on leadXpro’s single particle cryo-Electron Microscopy (cryo-EM) capabilities.

leadXpro’s team is committed to the application of biophysical and structure-based methods for the discovery and optimization of next-generation lead compounds with unmet efficacy and specificity. The startup specializes in membrane protein targets such as GPCR’s, ion-channels and transporters. leadXpro’s technology platform capitalizes on the expert knowledge regarding membrane protein biochemistry and close collaboration with academic facilities of the Paul Scherrer Institute (PSI) for synchrotron (SLS), X-ray Free Electron Laser (SwissFEL) and the University of Basel (C-CINA) for single particle cryo-electron microscopy (cryo-EM).

Recently, the startup signed a collaboration agreement with Sanofi to combine their structure-based drug discovery efforts and use leadXpro’s single particle cryo-Electron Microscopy (cryo-EM) capabilities for a challenging drug target. In particular, leadXpro will contribute protein sample generation and enable structure determination by high-resolution cryo-electron microscopy to inform about the interaction with small molecule ligands aiming to facilitate the discovery and optimization of novel lead molecules.

Wassim Abdul Rahman, project leader at leadXpro said: “We’re excited applying cutting-edge methods and in house developed unique expertise for expression, solubilization and purification to generate high-quality protein samples and structures suitable to visualize the ligand interaction by cryo-EM experiments. This effort redefines the discovery of new lead molecules for this challenging protein target”.
Please login or
register to comment

Please login or sign up to comment. Commenting guidelines



Give the people what they want



By continuing to use this website you agree with our TERMS AND CONDITIONS